首页|Cytotoxic immune cell-based immunotherapy for hepatocellular carcinoma

Cytotoxic immune cell-based immunotherapy for hepatocellular carcinoma

扫码查看
原文链接
  • NETL
  • NSTL
  • 维普
  • 万方数据
Hepatocellular carcinoma (HCC) is one of the most common solid tumors with poor clinical prognosis. Novel therapeutic regimens are urgently required for patients with advanced HCC. Both pre-clinical and clinical studies suggest immunotherapy as an attractive alternative for advanced HCC treatment. Natural killer (NK) cells and CD8+ T cells are the most important cytotoxic immune cells involved in cancer treatment and elimination. Reinvigorating the anticancer activity of NK and CD8+ T cells is the fundamental guarantee for the success of immunotherapy in advanced HCC treatment. Therefore, in this review, we aim to summarize the characteristics and roles of NK and CD8+ T cells in HCC development, describe the frontiers of immunotherapy for advanced HCC based on immune checkpoint inhibitors and adoptive cell transfer, and discuss their limitations and scope for future improvement.

Hepatocellular carcinomaimmunotherapynatural killer cellsCD8+ T cells

Jing Li、Longxiang Tao、Xuefu Wang

展开 >

School of Life Sciences, Anhui Medical University, Hefei 230032, Anhui, China

Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui, China

School of Pharmacy, Anhui Medical University, Hefei 230032, Anhui, China

This manuscript publication is funded by the Natural Science Foundation of China (31872741), Anhui Provincial Natural Science FoThis manuscript publication is funded by the Natural Science Foundation of China (31872741), Anhui Provincial Natural Science FoThis manuscript publication is funded by the Natural Science Foundation of China (31872741), Anhui Provincial Natural Science FoThis manuscript publication is funded by the Natural Science Foundation of China (31872741), Anhui Provincial Natural Science Fo

grant numbers: 1708085QH1831808085QC83Young Top Talent Program of Anhui Medical Universi

2020

10.20517/2394-5079.2019.34

肝癌研究(英文版)

肝癌研究(英文版)

ISSN：
年,卷(期)：2020.6(4)
  • 3