首页|Machine Perfusion Plus for Extended Criteria Donor Liver Grafts:Making Every Liver Count
Machine Perfusion Plus for Extended Criteria Donor Liver Grafts:Making Every Liver Count
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Transplantation represents the most effective treatment for end-stage liver diseases but is limited by the shortage of healthy donor organs.Extended criteria donor(ECD)liver grafts are increasingly utilized in clinical practice to mitigate this challenge.However,impaired ischemic tolerance of these grafts jeopar-dizes organ viability during cold storage.Machine perfusion(MP)was designed to improve organ preser-vation and reduce posttransplant complications.Nevertheless,it is increasingly evident that MP alone may not preserve ECD grafts optimally.Increasing emphasis has thus been placed on modified MP strate-gies,including the use of different perfusates,modified perfusion modalities,and different therapeutic interventions.Here,we introduce a novel term,"MP Plus,"denoting these additional strategies that are designed to restore organ function and potentially enable regeneration of ECD grafts.In this review,we summarize the existing and potential modified MP strategies and discuss their advantages in recon-ditioning different ECD grafts in clinical settings.
Zhejiang University School of Medicine,Hangzhou 310058,China
Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province,Hangzhou 310006,China
Department of Surgery,University of Cambridge & NIHR Cambridge Biomedical Research Centre,Cambridge CB2 2QQ,UK
Department of Surgery,Cambridge University Hospitals &NHS Foundation Trust,Cambridge CB2 2QQ,UK
Institute of Organ Transplantation,Zhejiang University,Hangzhou 310003,China
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国家重点研发计划Zhejiang University-Cambridge Global Partnership Fund国家自然科学基金国家自然科学基金浙江省重点研发计划Projects of Medical and Health Technology Program in Zhejiang Province
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