首页|Ionically Imprinting-Based Copper(Ⅱ)Label-Free Detection for Preventing Hearing Loss

Ionically Imprinting-Based Copper(Ⅱ)Label-Free Detection for Preventing Hearing Loss

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Copper is a microelement with important physiological functions in the body.However,the excess cop-per ion(Cu2+)may cause severe health problems,such as hair cell apoptosis and the resultant hearing loss.Therefore,the assay of Cu2+is important.We integrate ionic imprinting technology(IIT)and struc-turally colored hydrogel beads to prepare chitosan-based ionically imprinted hydrogel beads(IIHBs)as a low-cost and high-specificity platform for Cu2+detection.The IIHBs have a macroporous microstructure,uniform size,vivid structural color,and magnetic responsiveness.When incubated in solution,IIHBs rec-ognize Cu2+and exhibit a reflective peak change,thereby achieving label-free detection.In addition,bene-fiting from the IIT,the IIHBs display good specificity and selectivity and have an imprinting factor of 19.14 at 100 μmol·L-1.These features indicated that the developed IIHBs are promising candidates for Cu2+detection,particularly for the prevention of hearing loss.

Structural colorMicrofluidicsIonic imprintingLabel-free detectionHearing loss

Huan Wang、Hui Zhang、Xiaoli Zhang、Hong Chen、Ling Lu、Renjie Chai

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The Eighth Affiliated Hospital,Sun Yat-Sen University,Shenzhen 518033,China

Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging,Department of Biomedical Engineering,Shenzhen University,Shenzhen 518060,China

State Key Laboratory of Digital Medical Engineering,Department of Otolaryngology Head and Neck Surgery,Zhongda Hospital & Advanced Institute for Life and Health,Southeast University,Nanjing 210096,China

Department of Otolaryngology Head and Neck Surgery,Jiangsu Provincial Key Medical Discipline,Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School,Nanjing 210008,China

Co-Innovation Center of Neuroregeneration,Nantong University,Nantong 226001,China

Department of Otolaryngology Head and Neck Surgery,Sichuan Provincial People's Hospital,University of Electronic Science and Technology of China,Chengdu 610072,China

Institute for Stem Cell and Regeneration,Chinese Academy of S

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国家重点研发计划国家重点研发计划国家重点研发计划国家自然科学基金国家自然科学基金国家自然科学基金国家自然科学基金四川省科技厅项目Guangdong Basic and Applied Basic Research FoundationShenzhen Fundamental Research ProgramShenzhen Fundamental Research ProgramShenzhen Fundamental Research ProgramShenzhen Fundamental Research ProgramFutian Healthcare Research ProjectFutian Healthcare Research ProjectOpen Research Fund of State Key Laboratory of Genetic Engineering,Fudan UniversityFundamental Research Funds for the Central Universities,Sun Yatsen University

2021YFA11013002021YFA11018002020YFA0112503820300298197088292149304223022312021YFS03712023A1515011986JCYJ20190814093401920JCYJ20210324125608022JCYJ20190813152616459JCYJ20190808120405672FTWS2022013FTWS2023080SKLGE-210423qnpy153

2024

10.1016/j.eng.2023.09.001

工程(英文)

工程(英文)

CSTPCDEI
ISSN：2095-8099
年,卷(期)：2024.33(2)
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