The Notch Signaling Pathway:Mechanistic Insights in Health and Disease

扫码查看

原文链接

NETL
NSTL
万方数据

外文摘要：The Notch signaling pathway is evolutionarily conserved across metazoan species and plays key roles in many physiological processes.The Notch receptor is activated by two families of canonical ligands(Delta-like and Serrate/Jagged)where both ligands and receptors are single-pass transmembrane proteins usu-ally with large extracellular domains,relative to their intracellular portions.Upon interaction of the core binding regions,presented on opposing cell surfaces,formation of the receptor/ligand complex initiates force-mediated proteolysis,ultimately releasing the transcriptionally-active Notch intracellular domain.This review focuses on structural features of the extracellular receptor/ligand complex,the role of post-translational modifications in tuning this complex,the contribution of the cell membrane to ligand func-tion,and insights from acquired and genetic diseases.

外文关键词：

Notch signaling pathwayStructural biologyGlycosylationGenetic disordersCancerPharmacological agents

作者：

Yao Meng、Zhihan Bo、Xinyi Feng、Xinyi Yang、Penny A.Handford

展开 >

作者单位：

Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China

State Key Laboratory of Respiratory Health and Multimorbidity,Beijing 100050,China

Department of Biochemistry,University of Oxford,Oxford OX1 3QU,UK

基金：

Medical Research Council(MRC)GrantNational Natural Science Foundation of ChinaFundamental Research Funds for the Central UniversitiesCAMS Innovation Fund for Medical SciencesNational Natural Science Foundation of China

项目编号：

MR/V008935/18230459633320220572022-I2M-1-01681973383

出版年：

2024

DOI：

10.1016/j.eng.2023.11.011

工程(英文)

CSTPCDEI

ISSN：2095-8099

年,卷(期)：2024.34(3)