首页|Development of a Biodegradable,Cytocompatible,Antibacterial,and Biofilm-Controlling Chitosan Sulfobetaine Derivative Film as a Biological Material
Development of a Biodegradable,Cytocompatible,Antibacterial,and Biofilm-Controlling Chitosan Sulfobetaine Derivative Film as a Biological Material
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The purpose of this research was to develop a chitosan sulfobetaine(CS-SNCC)film via the solution-casting method as a biodegradable antibacterial material for biomedical applications.Chitosan and monochloro-triazine sulfobetaine were used as the raw materials for CS-SNCC preparation,and Fourier-transform infrared(FTIR),ultraviolet-visible(UV-Vis),energy-dispersive X-ray(EDX),and X-ray photoelectron spectroscopy(XPS)spectra were used to characterize and analyze the structure of the synthesized CS-SNCC.Furthermore,the swelling property,thermal stability,biodegradability,cyto-compatibility,and antibacterial properties of the CS-SNCC film were comprehensively investigated and compared with those of the chitosan film.The results for the film's enzymatic biodegradation behavior show that the CS-SNCC film undergoes a weight loss of 45.54％after 21 days of incubation.In addition,the CS-SNCC film effectively resists bacterial adhesion,prevents the formation of bacteria biofilms,and exhibits high antibacterial activity,with inactivation rates of 93.43％for Escherichia coli and 91.00％for Staphylococcus aureus.Moreover,the CS-SNCC film shows good cellular activity and cytocompatibility according to the cytotoxicity results.Therefore,the prepared biodegradable,cytocompatible,antibacte-rial,and biofilm-controlling CS-SNCC film has potential for biomedical applications.
School of Textile and Garment,Anhui Polytechnic University,Wuhu 241000,China
State Key Laboratory of New Textile Materials and Advanced Processing Technologies & Key Laboratory of Textile Fiber and Products,Ministry of Education & Hubei International Scientific and Technological Cooperation Base of Intelligent Textile Materials and Application,School of Textile Science and Engineering,Wuhan Textile University,Wuhan 430200,China
Department of Poultry Science,Auburn University,Auburn,AL 36849,USA
Starting Research Fund from the Anhui Polytechnic UniversityNatural Science Foundation of Anhui Province,ChinaHubei Provincial Central Leading Local Science and Technology Development Special Fund
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