首页|Enhanced Precision Therapy of Multiple Myeloma Through Engineered Biomimetic Nanoparticles with Dual Targeting

Enhanced Precision Therapy of Multiple Myeloma Through Engineered Biomimetic Nanoparticles with Dual Targeting

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Multiple myeloma(MM)is the second most prevalent hematological malignancy.Current MM treatment strategies are hampered by systemic toxicity and suboptimal therapeutic efficacy.This study addressed these limitations through the development of a potent MM-targeting chemotherapy strategy,which capi-talized on the high binding affinity of alendronate for hydroxyapatite in the bone matrix and the homolo-gous targeting of myeloma cell membranes,termed T-PB@M.The results from our investigations highlight the considerable bone affinity of T-PB@M,both in vitro and in vivo.Additionally,this material demonstrated a capability for drug release triggered by low pH conditions.Moreover,T-PB@M induced the generation of reactive oxygen species and triggered cell apoptosis through the poly(ADP-ribose)poly-merase 1(PARP1)-Caspase-3-B-cell lymphoma-2(Bcl-2)pathway in MM cells.Notably,T-PB@M prefer-entially targeted bone-involved sites,thereby circumventing systemic toxic side effects and leading to prolonged survival of MM orthotopic mice.Therefore,this designed target-MM nanocarrier presents a promising and potentially effective platform for the precise treatment of MM.

Multiple myelomaBortezomibDrug deliveryDual targetingControlled release

Ruogu Qi、Shanshan Wang、Jiayi Yu、Tianming Lu、Zhiqiang Bi、Weibo Liu、Yuanyuan Guo、Yong Bian、Jianliang Shen、Xuesong Zhang、Wenhao Hu

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School of Medicine,Nanjing University of Chinese Medicine,Nanjing 210023,China

Laboratory Animal Center,Nanjing University of Chinese Medicine,Nanjing 210023,China

Key Laboratory of Carcinogenesis and Translational Research,Ministry of Education/Beijing,Department of Radiation Oncology,Beijing Cancer Hospital,Beijing 100142,China

Department of Orthopedics,The Fourth Medical Center,The Chinese People's Liberation Army General Hospital,Beijing 100853,China

State Key Laboratory of Ophthalmology,Optometry and Vision Science,School of Biomedical Engineering,Wenzhou Medical University,Wenzhou 325027,China

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National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaJiangsu Talent Professor Program,Jiangsu Innovation Project of Graduate StudentNational Natural Science Foundation of Nanjing University of Chinese MedicineSpecial Grants of China Postdoctoral Science Foundation

5207314582004081KYCX23-2192NZY820040812021T140792

2024

10.1016/j.eng.2024.01.001

工程(英文)

工程(英文)

CSTPCDEI
ISSN：2095-8099
年,卷(期)：2024.36(5)
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