首页|Dietary Lipid Intervention in the Prevention of Brain Aging

Dietary Lipid Intervention in the Prevention of Brain Aging

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As people live longer,the burden of aging-related brain diseases,especially dementia,is increasing.Brain aging increases the risk of cognitive impairment,which manifests as a progressive loss of neuron function caused by the impairment of synaptic plasticity via disrupting lipid homeostasis.Therefore,supplemental dietary lipids have the potential to prevent brain aging.This review summarizes the important roles of dietary lipids in brain function from both structure and mechanism perspectives.Epidemiological and animal studies have provided evidence of the functions of polyunsaturated fatty acids(PUFAs)in brain health.The results of interventions indicate that phospholipids-including phosphatidylcholine,phos-phatidylserine,and plasmalogen-are efficient in alleviating cognitive impairment during aging,with plasmalogen exhibiting higher efficacy than phosphatidylserine.Plasmalogen is a recognized nutrient used in clinical trials due to its special vinyl ether bonds and abundance in the postsynaptic membrane of neurons.Future research should determine the dose-dependent effects of plasmalogen in alleviating brain-aging diseases and should develop extraction and storage procedures for its clinical application.

Brain agingNutritional interventionPhospholipidsPhosphatidylcholinePhosphatidylserinePlasmalogen

Wei Xiong、Bing Fang、Xiaoyu Wang、Ming Zhang、Min Du、Jiazeng Sun、Juan Chen、Yixuan Li、Changhao Sun、Xingen Lei、Xue Zhang、Fazheng Ren

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Key Laboratory of Precision Nutrition and Food Quality,Department of Nutrition and Health,China Agricultural University,Beijing 100083,China

Key Laboratory of Functional Dairy,Co-Constructed by the Ministry of Education and Beijing Municipality,College of Food Science and Nutritional Engineering,China Agricultural University,Beijing 100083,China

School of Food Science and Chemical Engineering,Beijing Technology and Business University,Beijing 100048,China

Department of Animal Science,Washington State University,Pullman,WA 99164,USA

Department of Nutrition and Food Hygiene,School of Public Health,Harbin Medical University,Harbin 150028,China

Department of Animal Science,Cornell University,Ithaca,NY 14853,USA

National Health Commission(NHC)and Chinese Academy of Medical Sciences(CAMS)Key Laboratory of Molecular Probe and Targeted Theranostics,Harbin Medical University,Harbin 150028,China

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National Key Research and Development Program of China111 Project from the Ministry of Education of the People's Republic of China

2022YFD2101003B18053

2024

10.1016/j.eng.2023.04.012

工程(英文)

工程(英文)

CSTPCDEI
ISSN：2095-8099
年,卷(期)：2024.37(6)
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