Natural Products Improve Organ Microcirculation Dysfunction Following Ischemia/Reperfusion-and Lipopolysaccharide-Induced Disturbances:Mechanistic and Therapeutic Views

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外文摘要：Microcirculatory disturbances are complex processes caused by many factors,including abnormal vaso-motor responses,decreased blood flow velocity,vascular endothelial cell injury,altered leukocyte and endothelial cell interactions,plasma albumin leakage,microvascular hemorrhage,and thrombosis.These disturbances involve multiple mechanisms and interactions among mechanisms that can include energy metabolism,the mitochondrial respiratory chain,oxidative stress,inflammatory factors,adhesion molecules,the cytoskeleton,vascular endothelial cells,caveolae,cell junctions,the vascular basement membrane,neutrophils,monocytes,and platelets.In clinical practice,aside from drugs that target abnor-mal vasomotor responses and platelet adhesion,there continues to be a lack of multi-target drugs that can regulate the complex mechanistic links and interactions underlying microcirculatory disturbances.Natural products have demonstrated obvious positive therapeutic effects in treating ischemia/reperfu-sion(I/R)-and lipopolysaccharide(LPS)-induced microcirculatory disturbances.In recent years,numer-ous research papers on the improvement of microcirculatory function by natural products have been published in international journals.In 2008 and 2017,the first listed author of this review was invited to publish reviews in the journal of Pharmacology & Therapeutics on the improvement of microcirculatory disturbances and organ injury induced by I/R using Salvia miltiorrhiza ingredients and other natural com-ponents of compounded Chinese medicine,respectively.This review systematically summarizes the effects,targets of action,and mechanisms of natural products regarding improving I/R-and LPS-induced microcirculatory disturbances and tissue injury.Based on this summary,scientific proposals are suggested for the discovery of new drugs to improve microcirculatory disturbances in disease.

外文关键词：

Ischemia/reperfusionLipopolysaccharideNatural productsLeukocyte activationHyperpermeability

作者：

Jingyan Han、Quan Li、Kai Sun、Chunshui Pan、Jian Liu、Ping Huang、Juan Feng、Yanchen Liu、Gerald A.Meininger

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作者单位：

Department of Integration of Chinese and Western Medicine,School of Basic Medical Sciences,Peking University,Beijing 100191,China

Tasly Microcirculation Research Center,Peking University Health Science Center,Beijing 100191,China

Key Laboratory of Stasis and Phlegm,State Administration of Traditional Chinese Medicine of the People's Republic of China,Beijing 100191,China

Beijing Laboratory of Integrative Microangiopathy,Peking University Health Science Center,Beijing 100191,China

Dalton Cardiovascular Research Center and Department of Medical Pharmacology and Physiology,University of Missouri,Columbia,MO 65211,USA

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基金：

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaState Key Laboratory of Core Technology in Innovative Chinese Medicine

项目编号：

818732178207431020221108

出版年：

2024

DOI：

10.1016/j.eng.2023.11.016

工程(英文)

CSTPCDEI

ISSN：2095-8099

年,卷(期)：2024.38(7)