Artificial Bear Bile:A Novel Approach to Balancing Medical Requirements and Animal Welfare

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外文摘要：Bear bile has been a valuable and effective medicinal material in traditional Chinese medicine(TCM)for over 13 centuries.However,the current practice of obtaining it through bear farming is under scrutiny for its adverse impact on bear welfare.Here,we present a new approach for creating artificial bear bile(ABB)as a high-quality and sustainable alternative to natural bear bile.This study addresses the scientific chal-lenges of creating bear bile alternatives through interdisciplinary collaborations across various fields,including resources,chemistry,biology,medicine,pharmacology,and TCM.A comprehensive efficacy assessment system that bridges the gap between TCM and modern medical terminology has been estab-lished,allowing for the systematic screening of therapeutic constituents.Through the utilization of chemical synthesis and enzyme engineering technologies,our research has achieved the environmentally friendly,large-scale production of bear bile therapeutic compounds,as well as the optimization and recomposition of ABB formulations.The resulting ABB not only closely resembles natural bear bile in its composition but also offers advantages such as consistent product quality,availability of raw materi-als,and independence from threatened or wild resources.Comprehensive preclinical efficacy evaluations have demonstrated the equivalence of the therapeutic effects from ABB and those from commercially available drained bear bile(DBB).Furthermore,preclinical toxicological assessment and phase Ⅰ clinical trials show that the safety of ABB is on par with that of the currently used DBB.This innovative strategy can serve as a new research paradigm for developing alternatives for other endangered TCMs,thereby strengthening the integrity and sustainability of TCM.

外文关键词：

Artificial bear bileChemical profileFormula optimizationPharmacodynamic consistencyPreclinical toxicological assessment

作者：

Yong Li、Yuhong Huang、Nan Feng、Heping Zhang、Jing Qu、Shuanggang Ma、Yunbao Liu、Jiang Li、Shaofeng Xu、Ling Wang、Mi Zhang、Jie Cai、Weiping Wang、Ru Feng、Hang Yu、Bo Yu、Dailiang Liang、Heping Qin、Suxiang Luo、Yanfen Li、Meifeng Li、Ruihua Wang、Chen Ma、Yan Wang、Xiaobo Cen、Xiaoxian Xu、Boli Zhang、Xiaoliang Wang、Shishan Yu

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作者单位：

State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100050,China

The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300250,China

Zhongshan Belling Biotechnology Co.,Ltd.,Zhongshan 528437,China

Zhongshan Anshi Biopharmaceutical Co.,Ltd.,Zhongshan 528437,China

WestChina-Frontier Pharma Tech Co.,Ltd.,Chengdu 610041,China

Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China

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基金：

Major Program of National Natural Science Foundation of ChinaCAMS Innovation Fund for Medical SciencesCAMS Innovation Fund for Medical Sciences

项目编号：

T2192970-T2192974CIFMS2021-12M-1-027

出版年：

2024

DOI：

10.1016/j.eng.2023.09.017

工程(英文)

CSTPCDEI

ISSN：2095-8099

年,卷(期)：2024.38(7)