Initial Experience of NIR-Ⅱ Fluorescence Imaging-Guided Surgery in Foot and Ankle Surgery

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外文摘要：Optical imaging in the second near-infrared(NIR-Ⅱ;900-1880 nm)window is currently a popular research topic in the field of biomedical imaging.This study aimed to explore the application value of NIR-Ⅱ fluorescence imaging in foot and ankle surgeries.A lab-established NIR-Ⅱ fluorescence surgical navigation system was developed and used to navigate foot and ankle surgeries which enabled obtaining more high-spatial-frequency information and a higher signal-to-background ratio(SBR)in NIR-Ⅱ fluores-cence images compared to NIR-Ⅰ fluorescence images;our result demonstrates that NIR-Ⅱ imaging could provide higher-contrast and larger-depth images to surgeons.Three types of clinical application scenar-ios(diabetic foot,calcaneal fracture,and lower extremity trauma)were included in this study.Using the NIR-Ⅱ fluorescence imaging technique,we observed the ischemic region in the diabetic foot before mor-phological alterations,accurately determined the boundary of the ischemic region in the surgical incision,and fully assessed the blood supply condition of the flap.NIR-Ⅱ fluorescence imaging can help surgeons precisely judge surgical margins,detect ischemic lesions early,and dynamically trace the perfusion pro-cess.We believe that portable and reliable NIR-Ⅱ fluorescence imaging equipment and additional func-tional fluorescent probes can play crucial roles in precision surgery.

外文关键词：

Second near-infrared fluorescence imagingFoot and ankle surgeryIndocyanine greenImaging-guided surgery

作者：

Xiaoxiao Fan、Jie Yang、Huwei Ni、Qiming Xia、Xiaolong Liu、Tianxiang Wu、Lin Li、Paras N.Prasad、Chao Liu、Hui Lin、Jun Qian

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作者单位：

Department of General Surgery,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou 310016,China

Centre for Optical and Electromagnetic Research & International Research Center for Advanced Photonics,College of Optical Science and Engineering,Zhejiang University,Hangzhou 310058,China

Department of Orthopedics,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou 310016,China

Institute for Lasers,Photonics,and Biophotonics,Department of Chemistry,State University of New York,Buffalo,NY 14260-3000,USA

Zhejiang Engineering Research Center of Cognitive Healthcare,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou 310016,China

College of Biomedical Engineering and Instrument Science,Zhejiang University,Hangzhou 310027,China

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基金：

Fundamental Research Fund for the Central UniversitiesNational Key Research and Development Program of ChinaNational Key Research and Development Program of ChinaNational Key Research and Development Program of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaZhejiang Engineering Research Center of Cognitive HealthcareNatural Science Foundation of Zhejiang ProvinceZhejiang Province Science and Technology Plan ProjectScience and Technology Innovation 2030 Plan Project

项目编号：

K202202202018YFC10050032018YFE01902002022YFB3206000U23A204878200187461975172821021052017E10011LQ22H1600172022C031342022ZD0160703

出版年：

2024

DOI：

10.1016/j.eng.2024.04.011

工程(英文)

CSTPCDEI

ISSN：2095-8099

年,卷(期)：2024.40(9)