Efficacy and Safety of Lianhua Qingke Tablets in the Treatment of Long Coronavirus Disease(COVID)Cough:A Randomized,Double-Blind,Placebo-Controlled,Multicenter Clinical Study

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外文摘要：Lianhua Qingke tablets,a patented traditional Chinese medicine that has validated clinical efficacy for treating cough caused by severe acute respiratory syndrome coronavirus 2 infection,lack rigorous evidence-based research evaluating their effect on long coronavirus disease(COVID)cough.A random-ized,double-blind,placebo-controlled,multicenter clinical study was conducted among patients with long COVID cough from 19 hospitals and 23 community health centers in China.Patients were random-ized 1:1 to receive either Lianhua Qingke tablets or placebo orally for 14 days(four tablets,1.84 g,three times a day).The primary endpoint indicator was the disappearance of cough,with the remission of cough also considered.Among 482 randomized patients,480(full analysis set 480;per-protocol set 470;safety set 480)were included in the primary analysis.According to the full analysis,the time until cough disappearance was significantly shorter in the trial group than in the control group,with a signifi-cant increase in the 14-day cough disappearance rate.Accordingly,the time to cough remission was sig-nificantly shorter in the trial group than in the control group.The change in the total symptom score was significantly greater in the trial group than in the control group on days 7 and 14,consistent with the results indicated by the visual analog scale(VAS)and cough evaluation test(CET)scores.No serious adverse events were recorded during the study.Lianhua Qingke tablets significantly improved the clinical symptoms of patients with long COVID cough.

外文关键词：

Long coronavirus disease(COVID)coughTraditional Chinese medicineClinical trialEfficacySafety

作者：

Xiaolong Xu、Jie Ying、Taiping Tian、Tengwen Liu、Chunhua Chi、Zhizhong Gong、Jingpeng Gao、Meiping Qian、Wei Tan、Ran Cao、Shuixian Lv、Zhougui Ling、Shuo Wang、Bo Li、Qingquan Liu

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作者单位：

Emergency Department,Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China

Beijing Institute of Traditional Chinese Medicine,Beijing 100010,China

Laboratory for Clinical Medicine,Capital Medical University,Beijing 100010,China

Medical College of Beijing Hospital of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100020,China

National Key Laboratory for Innovation and Transformation of Luobing Theory,Shijiazhuang 050000,China

Basic Medical College,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China

Department of General Medicine,Peking University First Hospital,Beijing 100034,China

Department of Pulmonary and Critial Care Medicine,Jiaxing Hospital of Traditional Chinese Medicine,Jiaxing 314000,China

Department of General Medicine,Shuangfeng People's Hospital of Taicang,Suzhou 215416,China

Respiratory Department,Weifang People's Hospital,Weifang 261000,China

Respiratory Department,Hebei Yiling Hospital,Shijiazhuang 050090,China

Department of Integrated Traditional Chinese and Western Medicine,Chengdu Xindu District Xindu Street Shudu Community Health Service Center,Chengdu 610500,China

Department of Pulmonary and Critial Care Medicine,Liuzhou Worker's Hospital,Liuzhou 545000,China

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基金：

National Multidisciplinary Innovation Team Project of Traditional Chinese MedicineBeijing Key Specialized Department for Major Epidemic Prevention and Control(Construction Project)

项目编号：

ZYYCXTD-D-202201Jingweiyi[2019]161

出版年：

2024

DOI：

10.1016/j.eng.2024.03.013

工程(英文)

CSTPCDEI

ISSN：2095-8099

年,卷(期)：2024.40(9)