首页|Wastewater Surveillance Provides Spatiotemporal SARS-CoV-2 Infection Dynamics

Wastewater Surveillance Provides Spatiotemporal SARS-CoV-2 Infection Dynamics

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Wastewater surveillance(WWS)can leverage its wide coverage,population-based sampling,and high monitoring frequency to capture citywide pandemic trends independent of clinical surveillance.Here we conducted a nine months daily WWS for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)from 12 wastewater treatment plants(WWTPs),covering approximately 80％of the population,to monitor infection dynamics in Hong Kong,China.We found that the SARS-CoV-2 virus concentration in wastewater was correlated with the daily number of reported cases and reached two pandemic peaks three days earlier during the study period.In addition,two different methods were established to esti-mate the prevalence/incidence rates from wastewater measurements.The estimated results from wastewater were consistent with findings from two independent citywide clinical surveillance pro-grammes(rapid antigen test(RAT)surveillance and serology surveillance),but higher than the cases number reported by the Centre for Health Protection(CHP)of Hong Kong,China.Moreover,the effective reproductive number(Rt)was estimated from wastewater measurements to reflect both citywide and regional transmission dynamics.Our findings demonstrate that large-scale intensive WWS from WWTPs provides cost-effective and timely public health information,especially when the clinical surveil-lance is inadequate and costly.This approach also provides insights into pandemic dynamics at higher spatiotemporal resolutions,facilitating the formulation of effective control policies and targeted resource allocation.

SARS-CoV-2Wastewater surveillancePrevalenceEffective reproductive number

Xiawan Zheng、Kathy Leung、Xiaoqing Xu、Yu Deng、Yulin Zhang、Xi Chen、Chung In Yau、Kenny W.K.Hui、Eddie Pak、Ho-Kwong Chui、Ron Yang、Hein Min Tun、Gabriel Matthew Leung、Joseph Tsz Kei Wu、Malik Peiris、Leo Lit Man Poon、Tong Zhang

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Environmental Microbiome Engineering and Biotechnology Lab,Center for Environmental Engineering Research,Department of Civil Engineering,The University of Hong Kong,Hong Kong 999077,China

WHO Collaborating Centre for Infectious Disease Epidemiology and Control,School of Public Health,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong 999077,China

Laboratory of Data Discovery for Health Litd.(D24H),Hong Kong 999077,China

The University of Hong Kong-Shenzhen Hospital,Hong Kong 999077,China

School of Public Health,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong 999077,China

Drainage Services Department,The Government of the Hong Kong Special Administrative Region,Hong Kong 999077,China

Environmental Protection Department,The Government of the Hong Kong Special Administrative Region,Hong Kong 999077,China

The Jockey Club School of Public Health and Primary Care,Faculty of Medicine,The University of Hong Kong,Hong Kong 999077,China

HKU-Pasteur Research Pole,The University of Hong Kong,Hong Kong 999077,China

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Health and Medical Research FundFood and Health BureauGovernment of the Hong Kong Special Administrative Region(SAR),ChinaInnovation and Technology Commission of the Government of the Hong Kong SARUniversity of Hong Kong for the postdoctoral fellowshipUniversity of Hong Kong for the Postgraduate Studentship

COVID1903015

2024

10.1016/j.eng.2024.01.016

工程(英文)

工程(英文)

CSTPCDEI
ISSN：2095-8099
年,卷(期)：2024.40(9)