首页|Biomimetic Erythrocyte-Like Particles from Microfluidic Electrospray for Tissue Engineering

Biomimetic Erythrocyte-Like Particles from Microfluidic Electrospray for Tissue Engineering

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Microparticles have demonstrated value for regenerative medicine.Attempts in this field tend to focus on the development of intelligent multifunctional microparticles for tissue regeneration.Here,inspired by erythrocytes-associated self-repairing process in damaged tissue,we present novel biomimetic erythrocyte-like microparticles(ELMPs).These ELMPs,which are composed of extracellular matrix-like hybrid hydrogels and the functional additives of black phosphorus,hemoglobin,and growth factors(GFs),are generated by using a microfluidic electrospray.As the resultant ELMPs have the capacity for oxygen delivery and near-infrared-responsive release of both GFs and oxygen,they would have excellent biocompatibility and multifunctional performance when serving as microscaffolds for cell adhesion,stimulating angiogenesis,and adjusting the release profile of cargoes.Based on these features,we demonstrate that the ELMPs can stably overlap to fill a wound and realize controllable cargo release to achieve the desired curative effect of tissue regeneration.Thus,we consider our biomimetic ELMPs with discoid morphology and cargo-delivery capacity to be ideal for tissue engineering.

BiomimeticsErythrocyteTissue engineeringMicrofluidicsElectrosprayOxygen delivery

Zhiqiang Luo、Lijun Cai、Hanxu Chen、Guopu Chen、Yuanjin Zhao

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Department of Rheumatology and Immunology,Nanjing Drum Tower Hospital,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,China

Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine,Vision and Brain Health),Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou 325001,China

National Key Research and Development Program of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNanjing Medical Science and Technique Development FoundationClinical Trials from Nanjing Drum Tower HospitalGuangdong Basic and Applied Basic Research FoundationShenzhen Fundamental Research ProgramShenzhen Fundamental Research Program

2020YFA0908200T22250035207306061927805ZKX210192022-LCYJ-ZD-012021B1515120054JCYJ20190813152616459JCYJ20210324133214038

2024

10.1016/j.eng.2023.08.022

工程(英文)

工程(英文)

CSTPCDEI
ISSN：2095-8099
年,卷(期)：2024.40(9)