首页|Skin Rejuvenation in Aged Mice by Fecal Microbiota Transplantation from Young Mice Feces

Skin Rejuvenation in Aged Mice by Fecal Microbiota Transplantation from Young Mice Feces

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Skin aging is an increasingly prominent topic in the context of healthy aging.During the aging process,the skin's barrier function diminishes,its water content decreases,wrinkles begin to form,and changes occur in the gut microbiota composition.However,the relationship between gut microbiota and skin aging remains unclear.In this study,we explored skin rejuvenation in aged mice through fecal microbiota trans-plantation(FMT)using feces from young mice.The results demonstrated enhanced water retention,thick-ened stratum corneum,increased collagen content,and improved epithelial cell differentiation in aged mice following FMT.Notably,FMT particularly increased the abundance of Lactobacillus and Lactococcus in aged mice,which were nearly undetectable in untreated aged mice.Non-targeted and targeted meta-bolomics analyses indicated that FMT significantly elevated levels of tryptophan(Trp)and its microbiota metabolites(e.g.,indole-3-lactic acid(ILA))in the feces and serum of aged mice.Both Trp and ILA appeared to rejuvenate aged skin by activating the aryl hydrocarbon receptor(AhR)to promote epidermal cell dif-ferentiation.In conclusion,FMT from young mice rejuvenated aged skin via Trp-metabolizing bacteria(Lactobacillus and Lactococcus)and Trp-derived metabolites,suggesting that interventions targeting Trp metabolites may effectively improve skin aging.

Skin agingFMTTryptophanIndole-3-lactic acidAhREpidermal differentiation

Shoujuan Yu、Ziyang Li、Xiaoxu Zhang、Qi Zhang、Liwei Zhang、Liang Zhao、Ping Liu、Jie Guo、Juan Chen、Chengying Zhang、Xinjuan Liu、Mengyang Yu、Dekui Jin、Xiaofeng Wang、Guang Li、Yan Cao、Fazheng Ren、Ran Wang

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Key Laboratory of Functional Dairy,Co-Constructed by Ministry of Education and Beijing Government,Department of Nutrition and Health,China Agricultural University,Beijing 100193,China

Advanced Innovation Center for Food Nutrition and Human Health,Department of Nutrition and Health,China Agricultural University,Beijing 100193,China

Research Center for Probiotics,China Agricultural University,Beijing 100083,China

Department of General Practice,The Third Centers of Chinese PLA General Hospital,Beijing 100039,China

Department of Gastroenterology,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China

Department of Gastroenterology,The Third Centers of Chinese PLA General Hospital,Beijing 100039,China

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2024

10.1016/j.eng.2024.08.005

工程(英文)

工程(英文)

CSTPCDEI
ISSN：2095-8099
年,卷(期)：2024.42(11)