Modifiers of the Effects of Vitamin D Supplementation on Cardiometabolic Risk Factors:A Systematic Review and Meta-Analysis

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外文摘要：The inconsistent findings concerning the effects of vitamin D supplementation on cardiometabolic risk fac-tors and the large heterogeneity in the published literature call for further research to identify sources of heterogeneity and potential effect modifiers.We performed a meta-analysis of randomized controlled tri-als(RCTs)published until March 2024 that reported estimates for the effects of vitamin D supplementation on cardiometabolic factors and relevant baseline covariates of RCT participants.A total of 17 656 partici-pants from 99 RCTs were analyzed,and weighted mean differences(95％confidence intervals(CI))for the intervention status were derived using random-effects modeling.Overall,compared with the placebo,vitamin D supplementation(median dose:3320 international unit(IU)·day-1;range 40-120 000 IU·day-1)had favorable effects on systolic blood pressure(SBP;-2.04(95％CI,-3.50,-0.59)mmHg;1 mmHg=0.133 kPa),diastolic blood pressure(DBP;-3.00(95％CI,-3.61,-2.39)mmHg),total cholesterol(TC;-0.12(95％CI,-0.21,-0.03)mmol·L-1),fasting blood glucose(FBG;-0.13(95％CI,-0.20,-0.05)mmol·L-1),hemoglobin A1C(A1C;-0.09％(95％CI,-0.13％,-0.05％)),and fasting blood insulin(FBI:-7.61(95％CI,-11.93,-3.30)pmol·L-1).The benefits of vitamin D were most evident in trials performed in non-Westerners,participants with baseline 25-hydroxyvitamin D(25[OH]D)lower than 15.0 ng·mL-1,non-obese(body mass index(BMI)＜30 kg·m-2),and older(age ≥ 50 years).The findings of this study underscore the need for personalized vitamin D intervention strategies that comprehensively account for individual patient characteristics(such as ethnocultural background,age,BMI,and circulating 25[OH]D level),intervention dosage,and intervention duration to optimize cardiometabolic health outcomes.

外文关键词：

Vitamin DCardiometabolic risk factorsMeta-analysisEthnocultural differencesObesity

作者：

Peng An、Sitong Wan、Langrun Wang、Tiancheng Xu、Teng Xu、Yonghui Wang、Jin Liu、Keji Li、Xifan Wang、Jingjing He、Simin Liu

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作者单位：

Food Laboratory of Zhongyuan,Luohe 462300,China

School of Food and Health,Beijing Technology & Business University,Beijing 100048,China

Institute of Environmental and Operational Medicine,Tianjin 300050,China

Systems Engineering Institute,Beijing 100010,China

Department of Nutrition and Food Hygiene,School of Public Health,Peking University,Beijing 100191,China

Department of Obstetrics and Gynecology,Columbia University,New York,NY 10032,USA

Center for Global Cardiometabolic Health,Departments of Epidemiology,Medicine,and Surgery,Brown University,Providence,RI02912,USA

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出版年：

2024

DOI：

10.1016/j.eng.2024.07.010

工程(英文)

CSTPCDEI

ISSN：2095-8099

年,卷(期)：2024.42(11)