Progress in Organ Bioprinting for Regenerative Medicine

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外文摘要：Organ damage or failure arising from injury,disease,and aging poses challenges due to the body's limited regenerative capabilities.Organ transplantation presents the issues of donor shortages and immune rejection risks,necessitating innovative solutions.The three-dimensional(3D)bioprinting of organs on demand offers promise in tissue engineering and regenerative medicine.In this review,we explore the state-of-the-art bioprinting technologies,with a focus on bioink and cell type selections.We follow with discussions on advances in the bioprinting of solid organs,such as the heart,liver,kidney,and pancreas,highlighting the importance of vascularization and cell integration.Finally,we provide insights into key challenges and future directions in the context of the clinical translation of bioprinted organs and their large-scale production.

外文关键词：

Organ printingThree-dimensional bioprintingRegenerative medicineTissue engineering

作者：

Xiang Wang、Di Zhang、Yogendra Pratap Singh、Miji Yeo、Guotao Deng、Jiaqi Lai、Fei Chen、Ibrahim T.Ozbolat、Yin Yu

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作者单位：

Center for Materials Synthetic Biology,Chinese Academy of Sciences Key Laboratory of Quantitative Engineering Biology,Shenzhen Institute of Synthetic Biology,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China

The Huck Institutes of the Life Sciences,Pennsylvania State University,University Park,PA 16802,USA

Engineering Science and Mechanics Department,Pennsylvania State University,University Park,PA 16802,USA

Department of Biomedical Engineering,Pennsylvania State University,University Park,PA 16802,USA

Materials Research Institute,Pennsylvania State University,University Park,PA 16802,USA

Department of Neurosurgery,Pennsylvania State College of Medicine,Hershey 17033,PA,USA

Pennsylvania State Cancer Institute,P

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出版年：

2024

DOI：

10.1016/j.eng.2024.04.023

工程(英文)

CSTPCDEI

ISSN：2095-8099

年,卷(期)：2024.42(11)