首页|Rotational Intravascular Multidirectional Ultrasound Catheter for Sonothrombolysis of Retracted Clots:An in Vitro and in Vivo Study
Rotational Intravascular Multidirectional Ultrasound Catheter for Sonothrombolysis of Retracted Clots:An in Vitro and in Vivo Study
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Thromboembolism in blood vessels poses a serious risk of stroke,heart attack,and even sudden death if not properly managed.Sonothrombolysis combined with ultrasound contrast agents has emerged as a promising approach for the effective treatment of thromboembolism.Recent reports have highlighted the potential of intravascular sonothrombolysis as a safe and effective treatment modality for deep vein thrombosis(DVT).However,its efficiency has not been validated through in vivo testing of retracted clots.This study aimed to develop a miniaturized multidirectional transducer featuring two 4-layer lead zir-conate titanate(PZT-5A)stacks with an aperture size of 1.4 mm × 1.4 mm,enabling both forward-and side-looking treatment.Integrated into a custom two-lumen 10-French(Fr)catheter,the capability of this device for intravascular sonothrombolysis was validated both in vitro and in vivo.With low-dose tissue plasminogen activators and nanodroplets,the rotational multidirectional transducer reduced the retracted clot mass(800 mg)by an average of 52％within 30 min during in vitro testing.The lysis rate was significantly higher by 37％than that in a forward-viewing transducer without rotation.This improvement was particularly noteworthy in the treatment of retracted clots.Notably,a long-retracted clot(＞10 cm)was successfully treated within 40 min in vivo by creating a flow channel with a diameter＞4 mm in a porcine DVT model.In conclusion,these findings strongly suggest the potential of this technique for clinical applications in sonothrombolysis,offering a feasible solution for effectively treating thromboembolism,particularly in challenging cases involving retracted clots.
Intravascular ultrasound catheterSonothrombolysis in vivoRetracted clots thrombolysis
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