Numerical Simulation of Patient-specific Hemodynamic in Pulmonary Arterial Hypertension
Pulmonary arterial hypertension is a fatal disease characterized by abnormally elevated pulmonary arterial pressure,which is directly affected by pulmonary artery hemodynamics.The numerical simulation of pulmonary arterial blood flow has great application prospects in clinical medicine.In this paper,three-dimensional modeling was performed to simulate blood flow in the pulmonary artery and its complex branches based on computed tomography(CT)images of normal subjects and patients with pulmonary hypertension,and the hemodynamics was analyzed.There are significant differences in the morphology of the pulmonary artery model between normal subjects and patients with pulmonary arterial hypertension,The patient's left and right pulmonary artery blood flow distribution ratio is unbalanced,and abnormal flow occurs in the branches.The overall wall pressure of patients is higher,and there is a wide range of low wall shear stress in the proximal pulmonary artery.The mean wall shear stress is lower than that of normal subjects.The numerical simulation of blood flow in pulmonary artery can provide reference for pathogenesis and clinical diagnosis.
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