Optimization of deep eutectic solvent-catalyzed preparation of diisooctyl adipate by response surface methodology
Deep eutectic solvents,as a new generation of green solvents,have attracted the attention of the scientific and tech-nological community because of their unique properties,such as simple synthesis and purification process,low cost of raw materials,renewable,and good biocompatibility.Deep eutectic solvents were prepared from p-toluenesulfonic acid-betaine,which were used as reaction solvents cum catalysts to catalyze the synthesis of diisooctyl adipate(DOA)plasticizers,solving the recycling problem of conventional catalysts.Using response surface methodology,three factors,namely,molar ratio of alkyd,molar ratio of catalyst and reaction temperature were selected,and the effects of the factors and their interactions on the esterification rate were analyzed by using Box-Behnken design with the esterification rate as the response value,and a polynomial regression equation model was obtained.The experimental results show that the optimal experimental conditions are alkyd molar ratio of 3.217,catalyst molar ratio of 2.310,and reaction temperature of 117.7℃.Under these conditions,the esterification rate of the synthesized DOA can reach 88.21%,which is close to the model prediction(92.112%).It is shown that the response surface methodology optimizes the process parameters for the catalytic synthesis of DOA by deep eutectic solvent with high accuracy and effectiveness.In addition,the esterifi-cation rate of this deep eutectic solvent remain at 80%after 8 times of cyclic testing.The product was identified as DOA through Fourier transform infrared spectroscopy and nuclear magnetic resonance hydrogen spectrometry.
deep eutectic solventcatalystester plasticizeresterificationgreen synthesisresponse surface methodology
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