Preparation and properties of waste biomass based porous hybrid sponge loaded with doxorubicin
In order to reduce the cardiotoxicity of doxorubicin,targeted transport of drug loading materials can reduce the concentration of doxorubicin in cardiac tissue,and the drug loading materials can be used for postoperative treatment and wound healing of skin melanoma.The existing drug loading materials often have the problem of low drug-loading rate or delivery efficien-cy.Chitosan(CS)extracted from marine waste biomass chitin and polyethylene glycol(PEG)were mixed with solution and freeze-dried to form a porous hybrid sponge.During the preparation process,the uniform dispersion of graphene oxide(GO)nanoflakes in the precursor gel was achieved through hydrogen bonding and charge attraction effects.The combination of GO adsorption and the unique drug loading performance of PEG was used to improve the drug loading efficiency of porous hybrid sponge for doxorubicin.The surface microstructure and mechanical properties of PEG-CS porous hybrid sponge were characterized and tested,the optimal mass ratio of PEG and CS was selected as 15∶2.According to the optimized ratio,GO/PEG/CS porous hybrid sponge(GPC-HS)containing different GO concentration gradient was further prepared.After verification of its drug loading efficiency,it is found that the pore structure in GPC-HS increases the contact area between the material and the drug,with a drug loading ratio of up to 66.8%for doxorubicin,and further achieves a sustained release effect.The sustained release time can be extended to 50 hours,and a release rate of up to about 90%can be achieved.These results indicate that PEG-CS porous hybrid sponge loaded with nano GO sheets has the ability to improve the loading and delivery efficiency of doxorubicin.
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