Niobium modified medical temperature-sensitive polylactic acid based polyurethane elastomer
Polylactic acid based polyurethane(PLA-TPU)has become a research hotspot for in vivo implant materials due to its good mechanical properties,abrasion resistance,biocompatibility and biodegradability.The temperature sensitive PLA-TPU can also be applied to special vivo implant materials,which will further promote the development of PLA-TPU in the field of in vivo implant materials.However,PLA-TPU does not have developability to ensure the safety in vivo without the addition of developer.In order to promote the better development performance of PLA-TPU in the field of biomaterials,the development modification of PLA-TPU was investigated.Niobium(Nb)is a biocompatible material for tissue engineering and has good development properties.Based on this,Nb as the developer was used to modify temperature sensitive PLA-TPU compared to the traditional developer barium sulfate(BaSO4)and the new generation developer bismuth chloride oxide(BiOCl).The effects of different developers on the development performance and temperature sensitivity of PLA-TPU were studied.The results show that Nb combines the advantages of BaSO4 and BiOCl,and has slight effect on the temperature sensitivity and better development modification effect on PLA-TPU,which is a good development modifier for medical thermosensitive materials.At the same time,PLA-TPU developed composites prepared with 40%Nb exhibit excellent development properties,temperature sensitivity and softness in vivo.PLA-TPU/40Nb has good development property,which is 1.65 times that of PLA-TPU.Its glass transition temperature was 30.54℃,indicating its temperature sensitivity in vivo.The modulus of from room temperature to the temperature of the falling rate was 74%,in line with the requirements of good temperature sensitive.Its storage modulus at body temperature is 117 MPa,and its flexibility is good.Therefore,PLA-TPU/40Nb has great potential as a temperature-sensitive medical catheter material for human implantation.
niobiumpolyurethanepolylactic acidX-ray imagingtemperature sensitivitycompositebiological material
NETL
NSTL
万方数据
