Construction of double network hydrogels and their application in biomedicine field
Double network hydrogels are polymers composed of two interpenetrating or semi-penetrating three-dimensional networks,which have high strength and toughness,and are widely used in the field of biomedicine.The construction method,forma-tion mechanism and properties of double-network hydrogels were reviewed from the aspects of chemical crosslinking,physico-chemical crosslinking,physical crosslinking and double-network nanocomposite.On this basis,the application of double-network hydrogels in biomedicine field was summarized from the aspects of medical dressing,drug carrier,biosensor and bone repair.Even-tually,the future research directions and application prospects of double-network hydrogels were predicted and prospected.