Molecular amplification time series prediction research combining Transformer with Kolmogorov-Arnold network
With the development of medical diagnosis and treatment intervention techniques,there has been an exponential growth in medical data along time series.Artificial intelligence(AI),particularly deep learning(DL),has demonstrated significant potential in uncovering medical data along time series.This study proposed,for the first time,a method that integrates the Transformer architecture with the Kolmogorov-Arnold network(KAN)to enable predictive analysis of nucleic acid amplification experimental data.Through experimental data analysis methods,the effectiveness of the model in accurately predicting amplification trends and endpoint values was validated,achieving an endpoint value error of merely 1.87 and an R-square coefficient as high as 0.98.Moreover,the model was capable of effectively identifying experimental data from different sample types.Furthermore,this research delved into the impact of the model's components and parameters on predictive performance through ablation experiments and hyperparameter tuning.Finally,a generalization capability test was conducted on 911 clinical data records provided by the Fujian Provincial Hospital across 10 deep learning models.The results demonstrated that the proposed Transformer-KAN network outperformed other models in terms of predictive accuracy and generalization capability.This study not only provided a new perspective for improving routine diagnostic techniques during pandemics but also offered empirical evidence for further research on the KAN model and its corresponding foundational theories.
deep learningtime series predictionnucleic acid amplification testKolmogorov-Arnold networkTransformer
万方数据
维普
