Pyrazoles are widely used in pharmaceuticals,pesticides and functional material molecules,and also as valuable intermediates for organic synthesis.In this paper,we investigated the reaction of acetophenones with N,N-dimethylformamide dimethyl acetal synthesis of the corresponding enaminone intermediates under transition metal-free conditions.Subsequently,the one-pot synthesis of pyrazoles by the reaction of enaminone intermediates with hydrazine hydrate.This cyclization reaction has the advantages of few synthetic steps,high yields and no use of expensive transition metals and ligands.The synthesized pyrazoles were subjected to GC-MS spectrometry and NMR for data characterization and structural identification.
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