Preparation and Sustained Release of aFGF/Sulfated Chito-Oligosaccharide Thermo-Sensitive Hydrogel
P407-P188 poloxamer and sulfonated chitosan oligosaccharide composite thermosensitive gel was prepared by synthesis reaction and loaded with aFGF for slow release protection of aFGF.SEM results showed that the composite thermosensitive gel was porous and layered,which was conducive to the adsorption of aFGF protein.The results of in vitro release experiment showed that the release of aFGF basically increased slowly and continuously after 5 days,indicating that the compound thermosensitive gel had the effect of slow and controlled release.Biocompatibility evaluation showed that aFGF sulfonated chitosan oligosaccharide thermosensitive gel had foreign body property in mice,but had no toxicity and antigenicity,and had good biocompatibility.
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