纤维素水凝胶敷料的制备工艺及新型敷料评价
Preparation of Cellulose Hydrogel Dressing and the Effect of a New Dressing
毛芮 1唐睿 1吴楠 1刘怡华 1马惠妍 1汤依群1
作者信息
- 1. 中国药科大学基础医学与临床药学学院,江苏南京 211100
- 折叠
摘要
水凝胶材料因其立体网状结构具有良好的保湿性和生物相容性,是作为伤口敷料的明星材料.本文对纤维素水凝胶的制备工艺进行总结,并评价一种基于微晶纤维素构造的新型惰性水凝胶敷料(纳好®抗菌护理液)对伤口愈合的影响.实验以形态学图像评价伤口愈合率,以HE病理切片染色评价肉芽填充和血管生成程度.酶联免疫吸附法检测TNF-α水平.与模型组比较惰性水凝胶敷料可以加速皮肤伤口愈合,且肉芽组织填充更致密.同时,使用惰性水凝胶敷料护理降低炎症因子浓度,各组间有统计学差异.
Abstract
Hydrogel materials are essential materials for wound dressings due to their three-dimensional network structure with good moisture retention and biocompatibility.In this study,the preparation process of cellulose hydrogel was summarized.And established a diabetic rat model with cortical defect to evaluate the effect of an inert hydrogel dressing constructed based on microcrystalline cellulose(NAHAO®)on wound healing.In the experiment,morphological images were used to evaluate the wound healing rate,and HE pathological section staining was used to evaluate the degree of granulation filling and angiogenesis.The levels of TNF-α were detected by ELISA.Compared with the model group,the inert hydrogel dressing could accelerate skin wound healing,and the granulation tissue filling was more dense.Meanwhile,the concentration of inflammatory factor TNF-α was decreased after inert hydrogel dressing nursing,and there was statistical difference among different groups.
关键词
水凝胶敷料/纤维素/纳好®/伤口愈合/微晶纤维素Key words
Hydrogel dressing/cellulose/NAHAO®/wound healing/microcrystalline cellulose引用本文复制引用
出版年
2024
NETL
NSTL
万方数据