Study the Mechanism of Xiheliu Chemical Compositions in the Treatment of Alcoholic Liver Diease Based on the Network Pharmacology and Molecular Docking Technology
Objective:To study the mechanism of Xiheliu in the treatment of alcoholic liver diease by network pharmacology and molecular docking methods.Methods:All the active ingredients and their targets were searched by TCMSP,and the oral availability(OB)≥30％and drug-like(DL)≥0.18 were selected.At the same time,GeneCards,DrugBank and other databases were used to screen alcoholic liver diease related targets.The intersection targets of Xiheliu and alcoholic liver diease were obtained by the VennDiagram software.The"disease-active ingredient-intersection target"network was constructed,and the core targets were screened for molecular structure processing and molecular docking.GO functional ennchment and KEGG pathway annotation analysis were performed.The results were visualized by R and Perl.Results:Quercetin,kaonferol,isorhamnetin and other major active ingredients of Xiheliu were screened,and 151 intersection targets of Xiheliu and alcoholic liver diease were identified.GO functional enrichment analysis identified 105 signaling pathways,and KEGG pathway enrichment screened 129 signaling pathways.Conclusion:This study preliminarly revealed that Xiheliu could treat alcoholic liver diease through multi-components,multi-targets and multi-path ways,which provided a theoretical basis for the development and utilization of natural medicinal plants.
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