Exploring the Mechanism of Action of Figs in the Treatment of Primary Hepatocellular Carcinoma Based on Network Pharmacology
Objective:To investigate the mechanism of figs in the treatment of primary liver cancer based on network pharmacology,to provide reference for further experimental and clinical studies on figs in the treatment of liver cancer,and to provide a theoretical basis for the further development of figs as food and medicine products.Methods:The main chemical components of figs and their targets were obtained from Herb database,and the active components of traditional Chinese medicine were screened according to ADME;the main targets of primary liver cancer were obtained from Gencards and OMIM databases,and protein interaction analysis was carried out by using the String platform,and the PPI network was constructed and analyzed;the Cytoscape 3.8.0 software was used to construct the Cytoscape 3.8.0 software was used to construct the"fig-chemical-target"interaction network.Results:The active ingredients of figs in the treatment of primary hepatocellular carcinoma included 6-(2-methoxy,cis-vinyl)-7-methylpyranocoumarin,N-methyllanthocyanidin,7,10,13-hexadecatrienoic acid methyl ester,methyl trans-linoleate,bergamot lactone,psoralen,and benzaldehyde,etc.The core targets of figs were SRC,MAPK1,MAPK3,and STAT3,HSP90AA1,AKT1,PIK3CA,MAPK14,RELA,LCK,etc.;the biological pathways of figs in the treatment of primary hepatocellular carcinoma mainly acted on the pathways of neuroactive ligand-receptor interactions,calcium signaling pathway,MAPK signaling pathway,etc.,and their functions were mainly to regulate the activity of protein serine/threonine kinases,etc.Conclusion:This study preliminarily reveals the multi-component,multi-target and multi-pathway mechanism of figs in the treatment of primary hepatocellular carcinoma,and provides a basis for the further development of fig food and drug products.
figprimary liver cancernetwork pharmacologymechanism of action
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