Progess in Ratiometric Fluorescent Probes for Reactive Oxygen Species
Reactive oxygen species(ROS)such as hydrogen peroxide(H2O2),hypochlorous acid(HC1O),nitroso-peroxide anion(ONOO),superoxide anion(O2),hydroxyl radical(HO·),singlet oxygen(1O2),etc.,which are widely present in organisms with high reactive oxygen activity.The spatial and temporal distribution of reactive oxygen species in living organisms has received unprecedented attention in the field of diseases such as cancer,arthritis,and Alzheimer's disease.Ratiometric fluorescent probes for ROS provide powerful tools for this field with their high sensitivity,accuracy and multi-channel in situ imaging.The design of ratiometric fluorescent probes requires a variety of photophysical properties,and this paper introduces the latest progress of ratiometric fluorescent probes for ROS according to intramolecular charge transfer(ICT),fluorescence resonance energy transfer(FRET),excited state intramolecular proton transfer(ESIPT),and Through-bond energy transfer(TBET).
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