Synthesis of Substituted 3-Iodo-1-Tosyl-1H-Indole by One-Pot Method
3-iodo-1-tosyl-1H-indole is a very important intermediate in organic synthesis.It is widely used in metal-catalyzed coupling reactions in fact.In this paper,the synthesis of 3-iodoindole protected by Ts group in the presence of different substituents were studied.Specifically,The target product was prepared by using N,N-dimethylformamide as the solvent,potassium hydroxide as the base,substituted indoles,iodine,4-toluenesulfonyl chloride as raw materials in one port.As a result,seventeen 3-iodo-1-tosyl-1H-indole containing different substituents were synthesized and their structures were confirmed by 1H-NMR.Under the condition of introducing different substituents,the one-pot synthesis of substituted 3-iodo-1-tosyl-1H-indole can be achieved successfully.This method is simple to operate and the products were easy to be purified without the need for column chromatography.Therefore,it is very suitable for industrial production.
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