手性分子印迹材料在毛细管电泳手性药物拆分中的应用
Application of Chiral Molecular Imprinting Materials in Chiral Drug Resolution by Capillary Electrophoresis
李宇晨 1杜迎翔1
作者信息
- 1. 中国药科大学 药物质量与安全预警教育部重点实验室,江苏 南京 210009;中国药科大学 天然药物活性组分与药效国家重点实验室,江苏 南京 210009
- 折叠
摘要
阐述了近年来基于手性分子印迹材料在毛细管电泳手性药物拆分中的应用研究与进展.通过归纳国内外最近的相关文献报道,对基于手性分子印迹材料毛细管柱的制备和通过毛细管电泳实现手性分离的相关研究进展和应用进行综述.通过报道可知将分子印迹材料用于毛细管柱的制备,可以显著提高手性药物在毛细管电泳中的分离度和拆分效果.手性分子印迹材料修饰的毛细管柱在毛细管电泳手性拆分领域具有良好的发展前景.
Abstract
This article elaborates on the application research and progress of chiral molecularly imprinted materials in capillary electrophoresis for chiral drug resolution in recent years.By summarizing recent literature reports both domestically and internationally,this article reviews the research progress and applications of the preparation of chiral molecularly imprinted material capillary columns and the implementation of chiral separation through capillary electrophoresis.According to reports,the use of molecularly imprinted materials in the preparation of capillary columns can significantly improve the resolution and resolution of chiral drugs in capillary electrophoresis.Chiral molecular imprinting materials modified capillary columns have good prospects in the field of capillary electrophoresis chiral resolution.
关键词
分子印迹/毛细管电泳/手性拆分/聚合物/手性识别Key words
molecularly imprinted/capillary electrophoresis/chiral resolution/polymer/chirality recognition引用本文复制引用
出版年
2024
NETL
NSTL
万方数据