摘要
Trop-2(Trophoblast surface antigen 2,滋养层细胞表面抗原2)蛋白是一种位于细胞膜上的膜糖蛋白,在胚胎发育和组织再生中起着重要的调节作用.Trop-2蛋白在正常组织中几乎不表达,而在肿瘤细胞中高表达.Trop-2 蛋白是抗肿瘤药物的一种理想靶点,正在广泛开发靶向Trop-2 的相关药物,其中抗体靶向药物是重要的研究方向.本文主要综述了当前在研发的靶向Trop-2 的抗体药物,如hRS7、Sacituzumab govitecan、Datopotamab Deruxtecan、RN927C、Trop-2 IgG Rap、SHR-A1921、DB-1305、BAT8003等.靶向Trop-2的抗体药物有着广泛的应用前景,不过也存在复杂的药代动力学特性和肿瘤渗透性较差等不足,有待开发更优的靶向Trop-2抗体药物.
Abstract
Trophoblast surface antigen 2(Trop-2)protein is a membrane glycoprotein located on the cell membrane,which plays an important regulatory role in embryonic development and tissue regeneration.Trop-2 protein is almost not expressed in normal tissues,but highly expressed in tumor cells.Trop-2 protein is an ideal target for antitumor drugs.Relevant drugs targeting Trop-2 are being widely developed,and antibody targeted drugs are an important research field.This work mainly introduces the antibody targeted drugs for Trop-2 protein,such as hRS7,Sacituzumab govitecan,Datopotamab Deruxtecan,RN927C,Trop-2 IgG Rap,SHR-A1921,DB-1305,BAT8003.Antibody drugs targeting Trop-2 have broad application.However,there are also some shortcomings,such as complex pharmacokinetic and poor tumor permeability,which need to develop better antibody drugs targeting Trop-2.
基金项目
绵阳市科技局中央引导地方科技发展资金定向转移支付项目(2022)(2022ZYDF085)
NETL
NSTL
万方数据