Antibody Drugs Targeting Trophoblast Surface Antigen 2 Protein
Trophoblast surface antigen 2(Trop-2)protein is a membrane glycoprotein located on the cell membrane,which plays an important regulatory role in embryonic development and tissue regeneration.Trop-2 protein is almost not expressed in normal tissues,but highly expressed in tumor cells.Trop-2 protein is an ideal target for antitumor drugs.Relevant drugs targeting Trop-2 are being widely developed,and antibody targeted drugs are an important research field.This work mainly introduces the antibody targeted drugs for Trop-2 protein,such as hRS7,Sacituzumab govitecan,Datopotamab Deruxtecan,RN927C,Trop-2 IgG Rap,SHR-A1921,DB-1305,BAT8003.Antibody drugs targeting Trop-2 have broad application.However,there are also some shortcomings,such as complex pharmacokinetic and poor tumor permeability,which need to develop better antibody drugs targeting Trop-2.