Network Pharmacology of Wuziyanzong Pills in the Treatment of Polycystic Ovary Syndrome
Objective:To investigate the potential mechanism of Wuziyanzong pills in the treatment of Polycystic ovary syndrome(PCOS)based on the method of network pharmacology of Chinese medicine.Methods:The target of PCOS disease in Disgenet,GeneCards and OMIM databases was retrieved by searching the component data of Cangfu Dantan pills in TCMSP.Biogenet was used to construct the protein interaction network between drugs and disease targets,and the intersection network was extracted to obtain the key target of Wuzi Yanzong Pill for PCOS treatment.GO and KEGG enrichment analysis of key targets were performed by Metascape,and the mechanism of action of Wuzi Yanzong pill in treating PCOS was obtained.Conclusion:The main components of Wuziyanzong pill in the treatment of PCOS may be quercetin,kaempferol,β-sitosterol,etc.The key pathways involved include cancer signaling pathway,lipid and atherosclerosis signaling pathway,chemocancer-receptor activation pathway,and T-interleukin-17 signaling pathway,etc.It is related to many biological processes such as hormone response,response to organic matter,cell response to lipids and response to exogenous stimuli.