含3,5-二正丁氧基苯基钌配合物的合成及抗菌活性研究
Synthesis and Antibacterial Activities of Ruthenium Complexes Containing 3,5-di-butyric Phenyl Groups
陈则文 1熊艳师 1廖向文 1王金涛1
作者信息
- 1. 江西科技师范大学 药学院,江西 南昌 330013
- 折叠
摘要
以含 3,5-二正丁氧基苯基取代邻菲啰啉衍生物(DBPIP)为主配体合成了一个多吡啶钌配合物Ru-1.通过最低抑菌浓度、时间杀伤曲线、生物被膜实验、耐药性评价等探索了钌化合物对金黄色葡萄球菌的抗菌活性.通过大蜡螟幼虫感染模型研究了Ru-1 的体内抗菌活性.结果表明,此钌配合物对金黄色葡萄球菌具有优良的抗菌活性.
Abstract
A polypyridine ruthenium complexes were synthesized with 3,5-di-butyxyphenyl derivatives as the main ligand(DBPIP):Ru-1.The antibacterial activities of ruthenium complexes against S.aureus was evaluated by the minimum inhibitory concentration,time killing curve,biofilm experiments and drug resistance study experiments.The antibacterial activity of Ru-1 was investigated by the model of infection.The results showed that this ruthenium complexes showed excellent antibacterial activity against S.aureus.
关键词
钌配合物/抗菌活性/抗菌机制/生物安全性/金黄色葡萄球菌Key words
ruthenium complex/antibacterial activity/antibacterial mechanism/Biosafety/Staphylococcus aureus引用本文复制引用
基金项目
国家自然科学基金(22067007)
国家自然科学基金(22067006)
出版年
2024
NETL
NSTL
万方数据