Research Progress in Asymmetric Friedel-Crafts Alkylation of Indoles Catalyzed by Organic Catalysts
Functionalized indoles are widely used in many research fields,so the synthesis of optically active indole derivatives is of great significance in organic synthesis.Catalytic asymmetric Friedel-Crafts alkylation is the most direct and thorough method to study the regioselective functionalization of indoles.In this paper,the progress of asymmetric Friedel-Crafts alkylation of indoles catalyzed by organic catalysts in recent 20 years is reviewed,and the summary and prospect are made.
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