Structure Identification and Mechanism Analysis of Degradation Impurities from Paeoniflorin-6'-O-benzene Sulfonate in Methanol
Objective:To study the structure of degradation impurities and degradation mechanism of paeoniflorin-6'-O-benzene sulfonate in methanol.Methods:The paeoniflorin-6'-O-benzene sulfonate was dissolved in methanol to form degradation impurities under heating conditions,then the two impurities were isolated by column chromatography and preparative HPLC.Their structures were confirmed by NMR,IR and MS,and the degradation mechanism was deduced.Results:Structure of two impurities of paeoniflorin-6'-O-benzene sulfonate in methanol were identified and the degradation mechanism was deduced.Conclusion:This study provides the material basis for the impurity research of paeoniflorin-6'-O-benzene sulfonate,as well as the scientific basis for the selection of the technological process,the development of analytical methods and the quality control.
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