Transdermal drug delivery as an non-invasive drug delivery method,it is gradually favored by the majority of medical workers and patients.However,the barrier function of the skin comeum limits the transdermal absorption of drugs.As an advanced drug carrier,lipid nanoparticles can effectively improve skin penetration and reduce drug-related side effects,which has a broad development prospect in the field of transdermal drug delivery.This paper reviewed the characteristics,penetration mechanism of lipid nanoparticles and discussed the application progress of lipid nanoparticles in transdermal drug delivery.The article clarified the broad development prospect of lipid nanoparticles in transdermal drug delivery,it provides reference for the development and clinical application of lipid nanoparticles.
关键词
脂质纳米粒/固体脂质纳米粒/纳米结构脂质载体/经皮给药/皮肤病
Key words
lipid nanoparticles/solid lipid nanoparticles/nanostructured lipid carriers/transdermal drug delivery/skin disease
维普
万方数据