首页|脂质纳米粒在经皮给药系统中治疗皮肤病的应用

脂质纳米粒在经皮给药系统中治疗皮肤病的应用

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经皮给药作为一种非侵入性给药方式,正逐渐受到广大医药工作者和患者的青睐.然而,皮肤角质层的屏障功能限制了药物的经皮吸收.脂质纳米粒作为一种新型的药物载体能够有效提高皮肤渗透性、减少药物相关副作用.本文就脂质纳米粒的特点、透皮作用机制以及在多种皮肤病中的应用做一综述,阐明脂质纳米粒在经皮给药领域的广阔发展前景,为脂质纳米粒的开发及临床应用提供参考.
Applications of Lipid Nanoparticles in Treating Skin Diseases in Transdermal Drug Delivery System
Transdermal drug delivery as an non-invasive drug delivery method,it is gradually favored by the majority of medical workers and patients.However,the barrier function of the skin comeum limits the transdermal absorption of drugs.As an advanced drug carrier,lipid nanoparticles can effectively improve skin penetration and reduce drug-related side effects,which has a broad development prospect in the field of transdermal drug delivery.This paper reviewed the characteristics,penetration mechanism of lipid nanoparticles and discussed the application progress of lipid nanoparticles in transdermal drug delivery.The article clarified the broad development prospect of lipid nanoparticles in transdermal drug delivery,it provides reference for the development and clinical application of lipid nanoparticles.

lipid nanoparticlessolid lipid nanoparticlesnanostructured lipid carrierstransdermal drug deliveryskin disease

刘静欢、孙立杰

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河北医科大学药学院,河北石家庄 050000

石家庄四药有限公司研发中心,河北石家庄 050000

化学药品无菌制剂产业技术研究院,河北石家庄 050000

河北省大容量注射剂工程技术研究中心,河北石家庄 050000

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脂质纳米粒 固体脂质纳米粒 纳米结构脂质载体 经皮给药 皮肤病

2024

广东化工
广东省石油化工研究院

广东化工

影响因子:0.288
ISSN:1007-1865
年,卷(期):2024.51(6)
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