Oligonucleotide drugs are DNA or RNA with different functional chemical modifications,mainly exerting therapeutic effects at the gene level.So far,16 oligonucleotide drugs have been approved for clinical treatment,which has led to an increasing interest in the biological analysis of oligonucleotide drugs.In particular,powerful biological analysis tools are needed to study the quality control and in vivo pharmacokinetics of these drugs.This review summarizes the advantages and disadvantages of liquid chromatography,capillary gel electrophoresis,and hybrid enzyme-linked immunosorbent assay in the detection of oligonucleotide drugs,providing some ideas for the research and quality control of such drugs.
关键词
寡核苷酸药物/仪器分析/液相色谱/毛细管凝胶电泳/杂交酶联免疫吸附
Key words
oligonucleotide drugs/instrument analysis/liquid chromatography/capillary gel electrophoresis/hybridized enzyme-linked immunosorbent assay
维普
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