Preparation,Evaluation and Advantages of Rasagiline Mesylate Ethosome
Objective:The purpose of this paper is to provide a preparation intermediate of Rasagiline mesylate transdermal drug delivery system,namely ethosomes.The purpose is to wrap the water-soluble drug Rasagiline mesylate in the carrier,and make the drug penetrate the skin by the affinity between the carrier and the skin.Methods:The preparation of Rasagiline Mesylate ethsomes were investigated by solvent injection method.Orthogonal experiments were designed to optimize the formulation by selecting the four factors that had the greatest influence.The optimal formulation and process were selected by using particle size and encapsulation rate as reference indexes and cumulative transdermal volume as decisive indexes.Results:The transmission rate and cumulative transmission rate(24 h)of Rasagiline Mesylate ethsomes were higher.After optimized formulation,the particle size of Resagiline mesylate was 138.73 nm and the encapsulation rate was 58.80%.The cumulative transdermal volume per unit time(24 h)was about 600 ug.Conclusion:The advantages of ethosomes as drug delivery carrier were explained.
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