Preparation of Compound Atractylodis Rhizoma Volatile Oil Microemulsion
Objective:The prescription of compound Atractylodis Rhizoma volatile oil microemulsion was screened,and the preparation conditions were investigated.Methods:According to the mutual solubility of compound Atractylodis Rhizoma volatile oil and oil phase,emulsifier and co-emulsifier,the preliminary screening was carried out.Then,by drawing the pseudo-ternary phase diagram,considering the area of microemulsion area,the appearance and stability of microemulsion,the prescription composition was finally determined.On this basis,the preparation temperature,stirring speed and stirring time of microemulsion were further studied,and the particle size of microemulsion was determined.Results:The preparation process of compound Atractylodis Rhizoma volatile oil microemulsion was as follows:EL-40 and isopropanol were mixed at a mass ratio of 3∶1 to obtain a mixed emulsifier,and then the equal mass of compound Atractylodis Rhizoma volatile oil and ethyl oleate were mixed as the oil phase.The mixed emulsifier and oil phase were mixed at a mass ratio of 8∶2,and distilled water was added at 300 r/min,30±5℃.Stirring for 10～15 min to form a clear and transparent microemulsion.The average particle size of the microemulsion was 20.71 nm,the dispersion coefficient was 0.019.Conclusion:The preparation process of compound Rhizoma Atractylodis volatile oil microemulsion is simple and feasible.The microemulsion is clear and transparent,with small particle size,uniform distribution and good stability.
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