冬凌草甲素荧光碳量子点的制备及其在生物成像中的应用
Preparation of Fluorescent Carbon Quantum Dots of Oridonin for Bioimaging Applications
罗坤顺 1汪祖华 1朱月 1陈滕 1陈智勇 1杨菁 1俸婷婷2
作者信息
- 1. 贵州中医药大学 药学院,贵州 贵阳 550025;贵州中医药大学纳米药物技术研究中心,贵州 贵阳 550025
- 2. 贵州中医药大学 药学院,贵州 贵阳 550025;贵州中医药大学药食两用资源应用与开发研究中心,贵州 贵阳 550025
- 折叠
摘要
碳量子点具有独特的荧光性质,是一种优良的光致发光材料.由于其良好的生物相容性,在生物医学成像领域得到了广泛的应用.然而,具有抗肿瘤活性的碳量子点却少有报道.冬凌草甲素(ORI)是一种抗癌药物,对多种类型的肿瘤细胞都有明显的抑制作用.本研究采用一种简单的溶剂一步水热法合成了具有荧光和抗肿瘤活性的 ORI-CDs,并用透射电子显微镜、傅里叶变换红外光谱和X射线单晶衍射以及拉曼光谱对其进行了表征.光学性质的研究表明,ORI-CDs表现出优秀的光致发光性能.此外,我们观察了ORI-CDs的抗肿瘤活性和体内外荧光成像性能.我们的结果表明,ORI-CDs 既可以作为生物成像材料,也可以作为抗肿瘤药物,这表明它们在未来的临床应用中具有巨大的潜力.
Abstract
Carbon quantum dots have unique fluorescent properties and are an excellent photoluminescent material.Due to their good biocompatibility,they have been widely used in biomedical imaging.However,carbon quantum dots with anti-tumor activity have been rarely reported.Oridonin(ORI)is an anticancer drug with significant inhibitory effects on many types of tumor cells.In the present study,ORI-CDs with fluorescence and antitumor activity were synthesized by a simple solvent-based one-step hydrothermal method and characterized by transmission electron microscopy,Fourier transform infrared spectroscopy and X-ray single-crystal diffraction as well as Raman spectroscopy.The study of optical properties showed that the ORI-CDs exhibited excellent photoluminescence properties.In addition,we observed the antitumor activity and ex vivo fluorescence imaging properties of ORI-CDs.Our results indicate that ORI-CDs can be used as both bioimaging materials and antitumor drugs,suggesting that they have great potential for future clinical applications.
关键词
冬凌草甲素/碳量子点/抗肿瘤活性/生物成像Key words
oridonin/carbon quantum dots/anti-tumor activity/bioimaging引用本文复制引用
出版年
2024
NETL
NSTL
万方数据