Preparation of Fluorescent Carbon Quantum Dots of Oridonin for Bioimaging Applications
Carbon quantum dots have unique fluorescent properties and are an excellent photoluminescent material.Due to their good biocompatibility,they have been widely used in biomedical imaging.However,carbon quantum dots with anti-tumor activity have been rarely reported.Oridonin(ORI)is an anticancer drug with significant inhibitory effects on many types of tumor cells.In the present study,ORI-CDs with fluorescence and antitumor activity were synthesized by a simple solvent-based one-step hydrothermal method and characterized by transmission electron microscopy,Fourier transform infrared spectroscopy and X-ray single-crystal diffraction as well as Raman spectroscopy.The study of optical properties showed that the ORI-CDs exhibited excellent photoluminescence properties.In addition,we observed the antitumor activity and ex vivo fluorescence imaging properties of ORI-CDs.Our results indicate that ORI-CDs can be used as both bioimaging materials and antitumor drugs,suggesting that they have great potential for future clinical applications.
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