基于MCM41掺杂的萘普生印迹整体柱的制备及研究
Preparation and Study of Naproxen Imprinted Monolithic Columns based on MCM41 Doping
赵丽丽 1孟鑫 1贾明之 1黄艳萍 1刘照胜1
作者信息
- 1. 天津医科大学药学院,天津 300070;天津市临床药物关键技术重点实验室,天津 300070
- 折叠
摘要
本研究通过分子印迹技术以原位聚合法成功合成了 MCM41-MPS 掺杂的萘普生印迹整体柱.通过改进配方进而考察色谱条件,实现印迹因子最高达 10.7,相比未掺杂 MCM41-MPS 的印迹整体柱,印迹因子提高两倍多.结果表明,MCM41-MPS MIP 比MIP 具有更高的保留因子和印迹因子,并通过傅立叶红外吸收光谱(FT-IR)和扫描电子显微镜(SEM)对聚合物进行表征,采用 Langmuir拟合得到MCM41-MPS MIP的最大吸附量为10.89 mg/g,最终,对湖水中加标的萘普生进行固相萃取,回收率达96.40%.
Abstract
In this study,MCM41-MPS-doped naproxen imprinted monolithic columns were successfully synthesized by molecularly imprinted technique with in situ polymerization.By improving the formulation and then examining the chromatographic conditions,an imprint factor of up to 10.7 was achieved,which was more than two times higher than that of the undoped MCM41-MPS imprinted monolithic column.The results showed that MCM41-MPS MIP had higher retention and blotting factors than MIP,and the polymer was characterized by Fourier infrared absorption spectroscopy(FT-IR)and scanning electron microscopy(SEM),and the maximum adsorption amount of MCM41-MPS MIP was obtained to be 10.89 mg/g by using Langmuir fitting,and ultimately,the spiked lake water was spiked with naproxen was subjected to solid phase extraction with a recovery of 96.40%.
关键词
MCM41/萘普生/分子印迹整体柱/吸附富集Key words
MCM41/naproxen/molecularly imprinted monolithic column/adsorption enrichment引用本文复制引用
基金项目
天津市自然科学基金重点项目(19JCZDJC36400)
出版年
2024
NETL
NSTL
万方数据