Study on the Hypoglycemic Effect of Citrus Flavonoids on Mice
Objective:To investigate the hypoglycemic effect of citrus flavonoids on diabetic mice induced by alloxouracil.Methods:The study utilized citrus peel as the raw material,with the extraction rate of flavonoids serving as the index.The extraction method and process conditions were optimized,followed by the establishment of a mouse diabetes model through intraperitoneal injection of alloxan.Subsequently,the mice were randomly divided into different groups:diabetes model group,glibenuride positive group,and different dose citrus peel flavonoid group.Gavage was administered according to the corresponding dose while recording changes in body weight and blood sugar levels on mice.Results:The blood glucose levels in the model group exhibited a significant increase without any treatment intervention(P＜0.05).Following 10 consecutive days of intragastric administration,the high-dose,medium-dose,and drug groups demonstrated significantly lower blood glucose levels compared to the model group.Moreover,the medium-dose group exhibited a more pronounced hypoglycemic effect than the high-dose group.Conclusion:citrus flavonoids effectively reduces blood sugar levels in diabetic mice,providing a theoretical foundation for diabetes treatment and drug development.
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