鞣花酸对胃癌细胞生长及迁移的作用研究
Studies on the Effect of Ellagic Acid on the Growth and Migration of Gastric Cancer Cells
李色杰 1梁锦 1罗清淋 1黄龙江 1郑广进 1黄桔1
作者信息
- 1. 广西民族师范学院 化学与生物工程学院,广西 崇左 532200
- 折叠
摘要
目的:探讨鞣花酸对胃癌细胞BGC823 的生长及迁移能力的影响.方法:体外培养BGC823 细胞,采用MTT法检测细胞活力;采用相差显微镜观察细胞形态;采用细胞划痕实验观察细胞的迁移能力.结果:鞣花酸可显著降低 BGC823 细胞活力;经鞣花酸干预后,细胞皱缩,细胞碎片增加;鞣花酸可降低BGC823 细胞的迁移能力.结论:鞣花酸对BGC823 细胞具有明显的抑制生长及迁移的作用.
Abstract
Objective:To investigate the effects of ellagic acid on the growth and migration ability of gastric cancer cells BGC823.Methods:BGC823 cells were cultured in vitro,and cell viability was detected by MTT assay;cell morphology was observed by phase contrast microscopy;and cell migration ability was observed by cell scratch assay.Results:Ellagic acid significantly reduced the viability of BGC823 cells;after intervention with ellagic acid,the cells were wrinkled and the cellular debris increased;ellagic acid reduced the migration ability of BGC823 cells.Conclusion:Ellagic acid has a significant inhibitory effect on the growth and migration of BGC823 cells.
关键词
胃癌细胞/鞣花酸/迁移/生长/BGC823细胞Key words
gastric cancer cells/ellagic acid/migration/growth/BGC823 cells引用本文复制引用
基金项目
自治区级大学生创新创业训练计划立项项目(2023)(S202310604137)
出版年
2024
NETL
NSTL
万方数据