摘要
柯萨奇病毒B型(Coxsackieviruses B,CVB)是一种微小、无包膜的单正链RNA病毒,属于小核糖核酸病毒科(Picornaviridae)肠道病毒属(Enterovirus),主要经消化道传播.CVB感染可以引起多种疾病,如手足口病、腹泻、急性心肌炎、无菌性脑膜炎、骨髓炎及出疹性疾病等.此外,CVB 感染也是Ⅰ型糖尿病的诱发因素,严重威胁人们健康.目前,越来越多的天然和人工合成化合物以及单克隆抗体等已经被用于CVB感染的治疗,但是高效抗CVB药物仍然缺乏.本文对抗CVB病毒的药物进行综述,以期为CVB的预防、治疗和药物研发提供思路和依据.
Abstract
Coxsackieviruses B(CVB)are small,non-enveloped,single-stranded RNA viruses belonging to the Enterovirus genus of the Picornaviridae family,which is mainly transmitted through the digestive tract.CVB infections can cause a variety of diseases,such as hand foot and mouth disease,diarrhea,acute myocarditis and pericarditis,aseptic meningitis,osteomyelitis and rash and fever illness.In addition,CVB is the most incriminated environmental factor associated with the development of chronic diseases like type Ⅰ diabetes(TID).It is a serious threat to people's health.At present,more and more types of compounds including natural and synthetic compounds,monoclonal antibodies,etc.,have been used in the treatment of CVB,but the lack of effective anti-CVB drugs is still a problem to be solved.Therefore,this article reviewed the etiology and epidemiology of CVB virus and current related drugs,providing potential ideas and basis for the prevention,treatment and drug research and development of CVB.
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