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芦丁分子印迹聚合物的制备及其应用

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本文以MCM-48 为载体,为芦丁(RT)为模板分子,3-羧酸苯硼酸(CPBA)为功能单体制备芦丁分子印迹聚合物(RT-MIPs),使用紫外-可见分光光度计进行含量测定。优化制备条件,当CPBA为 50 mg、间苯二酚与甲醛用量摩尔比为 1∶2、pH为8。5时,RT-MIPs对目标分子RT的吸附能力最佳,吸附量为 14。80 mg/g。对实际样品(槐花、荞麦、玉米须、红枣)进行加标回收实验,回收率为95。43%~106。07%,该方法设计合理。表明RT-MIPs具有较好的实际应用前景,有望用于天然药物活性成分RT的快速选择性分离提取,为其分离和富集提供了一条新的途径。
Preparation and Application of Rutin Molecularly Imprinted Polymer
Using MCM-48 as the sacrificial carrier,rutin(RT)as the template molecule,and 3-carboxylic phenylboronic acid(CPBA)as the functional monomer,Rutin-based molecularly imprinted polymers(RT-MIPs)were prepared.The content was determined using a UV-Vis spectrophotometer;The preparation conditions were optimized.When CPBA is 50 mg,the molar ratio of resorcinol to formaldehyde is 1∶2,and pH is 8.5,the adsorption capacity of RT-IMPs to target molecule RT was the best,and the adsorption capacity was 14.80 mg/g.The actual samples(Sophora,buckwheat,corn,jujube)were marked recovery experiment,the recovery rate was 95.43%~106.07%,the design of this method was reasonable.This shows that RT-MIPs have promising practical applications and are expected to be used for the rapid and selective separation and extraction of the active ingredient RT in natural drugs,providing a new approach for their isolation and enrichment.

Rutinboron affinitymolecularly imprintedpolymersenrichment

侯星羽、朱家莹、沈景辉、边新新、丁立新

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佳木斯大学 药学院,黑龙江 佳木斯 154000

芦丁 硼亲和 分子印迹 聚合物 富集

2024

广东化工
广东省石油化工研究院

广东化工

影响因子:0.288
ISSN:1007-1865
年,卷(期):2024.51(8)