In this paper,the solubility of trimethoprim in water was firstly determined,and then the solubility enhancement study of trimethoprim was carried out by using surfactant solubilisation,β-cyclodextrin inclusion,solid dispersion and other solubilisation techniques commonly used in pharmaceutical science.The results showed that the solubility of trimethoprim in water was 0.31 mg/mL,and the highest solubility of trimethoprim in water was 0.37 mg/mL,7.06 μg/mL and 3.3 mg/mL after using solubilization techniques of surfactant solubilization,β-cyclodextrin inclusion and solid dispersion,respectively.The comparison of the three solubilisation techniques illustrates that the optimal method of solid dispersion preparation is the solvent method,the optimal carrier is PVP K30 and the optimal freezing time is 2 h.The concentration of trimethoprim in the solid dispersion solution can reach 3.3 mg/mL,which is 10.64 times more concentrated than the ordinary aqueous solution of trimethoprim compared to its own solubility of 0.31 mg/mL.The solubility of trimethoprim in water was improved effectively.
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