Amethod for the Determination of Trace Amounts of Ethyl Acetate by Gas Chromatography
Objective:To establish an analytical method for the determination of trace amounts of ethyl acetate by direct injection gas chromatography.Methods:The optimal analytical conditions were determined by optimizing the instrument parameters,including inlet temperature,initial column temperature,column flow rate,and split ratio:column SH-PolarWax(30 m×0.32 mm 0.25 μm),programmed ramp-up:initial temperature of 45℃,hold for 4min,ramp-up to 90℃at 10℃/min,then ramp-up to 200℃at 20℃/min;inlet temperature of 220℃,flow rate of 1.00 mL/min,shunt ratio of 10∶1.Results:Under the optimized chromatographic conditions,the test method for the determination of trace amounts of ethyl acetate showed good linearity in the range of 0.01～1.00 μg/mL with correlation coefficients(r)greater than 0.999,recoveries in the range of 90%～110%,RSDs(n=3)all less than 5%,detection limits of 0.004 μg/mL and quantification limits of 0.012 μg/mL.Conclusions:The method has the characteristics of short detection time and high sensitivity,and the research results can provide data support and reference for the research of ethyl acetate content detection method.
ethyl acetategas chromatographycondition optimizationdirect injectionexternal standard method
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