The sustained release preparation of compound Blumea balsamifera nanocapsules was achieved through cyclodextrin inclusion technology.The preparation process of compound Blumea balsamifera nano-microcapsules was optimized through single factor experiments,and their particle size and micro-morphology were characterized.The sustained release effect of the compound Blumea balsamifera nano-microcapsule perfume was evaluated through a retention experiment,and its refreshing effect was assessed using a weight-bearing swimming test.The nanocapsules prepared in this study were uniformly dispersed with a particle size of 838±80.52 nm,and had good sustained release properties,which could significantly extend the time to fall asleep of fatigue mice.The preparation technique for nano-microcapsules exhibits a strong encapsulation effect on compound essential oils,facilitating their gradual release.This addresses issues related to the short-lived scent of aromatic essential oils and offers innovative opportunities for the advancement of anti-fatigue compound traditional Chinese medicine perfumes.