Study on the Mechanism of Total Flavonoids of Epimedium in Preventing and Treating Alzheimer's Disease Based on Network Pharmacology
To analyze the mechanism of total flavonoids of Epimedium in the treatment of Alzheimer's disease using network pharmacology analysis method.By utilizing the Network Pharmacology Database and Analysis Platform(TCMSP),the effective active ingredients in Epimedium were obtained,form which the total flavonoids were screened.By combining the Pubchem database with the Swiss Target Prediction database,corresponding targets for each flavonoid component were selected;Using the Gene Cards database to obtain genes related to Alzheimer's disease;Using Cytoscape 3.9.1 software to construct a"flavonoid active ingredient-target-disease"network for Epimedium;Using the Venny2.1.0 platform to obtain the intersection targets of total flavonoids and Alzheimer's disease,and then inputting the intersection targets into the STRING 11.0 database to obtain the protein protein interaction(PPI)network diagram;Conduct GO function and KEGG pathway enrichment analysis through the Metascape database.Results:Twelve core components of total flavonoids of Epimedium in the treatment of Alzheimer's disease were obtained,and 10 core targets included AKT1,TNF,VEGFA,SRC,etc.,including cancer pathway,Relaxin signaling pathway,EGFR Tyrosine kinase inhibitor resistance and other signaling pathways.Conclusion:The constructed"component target pathway"network structure diagram reveals the synergistic effect of multiple components,targets,and pathways of Epimedium flavonoids on Alzheimer's disease,providing a theoretical basis for further elucidating the mechanism of Epimedium's anti Alzheimer's disease.
network pharmacologytotal flavonoids of Epimediumalzheimer's diseasemechanismepimedium
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